发明名称 |
Therapeutic insulin preparation and a process for the production of a stable insulin preparation with protracted effect |
摘要 |
Novel stable insulin preparations with protracted action and reduced or no antigenicity are obtained by reacting insulin free of antigenic impurities with an organic compound having basic amino groups, preferably a basic polypeptide or a cleavage product of a basic polypeptide, such as protamine, in a buffered protein dissociating or protein depolymerizing aqueous medium. Examples of preferred protein dissociating or protein depolymerizing media are aqueous solutions containing urea, a lower alkanol dialkylformamide, acetamide, N-alkyl-acetamide or acetonitrile.
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申请公布号 |
US4183849(A) |
申请公布日期 |
1980.01.15 |
申请号 |
US19770858916 |
申请日期 |
1977.12.08 |
申请人 |
NORDISK INSULINLABORATORIUM |
发明人 |
ANDRESEN, FINN H;HANSEN, BRUNO A |
分类号 |
A61K9/00;A61K38/00;A61K47/48;C07K14/625;(IPC1-7):A61K37/26 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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