| 摘要 |
<p>1,4-Dihydropyridines characterized by a carbo(arylalkoxy) group in the 5-position, an aryl group in the 4position and a alkanoyl or carbalkoxy group in the 3-position and further optionally substituted in the 1, 2 and 6-positions are prepared through the reaction of an ylidene-.beta.-dicarbonyl compound, which may be generated in situ from the corresponding .beta.-dicarbonyl compound and an aldehyde, and an enaminocarboxylic acid ester, which may also be generated in situ from a .beta.-dicarbonyl compound and an amine. The compounds, of which 2,6-dimethyl-3-carbomethoxy-4-(2-nitrophenyl)-5-carbo-benzoxy-1,4-dihydropyridine is a representative embodiment, are coronary dilating, spasmolytic and hypotensive agents.</p> |
