摘要 |
Novel substituted N-[1-(3,4-methylenedioxyphenyl)-propyl-(2)]-N'-phenylpiperazines of the formula I shown, wherein either R1 and R2 denote chlorine or R1 denotes methyl and R2 denotes methoxy, are prepared by reacting an appropriately substituted ethylenediamine by N-alkylation methods with a compound of the formula X-CH2-CH2-X, wherein X denotes an anionically easily cleavable radical, preferably a halogen atom. The reaction is advantageously carried out in the presence of an acid-binding agent and at an elevated temperature. The compounds of the formula I may be obtained in the form of the racemates or of the optically active antipodes. The products of the process show a good central-depressant action as well as an excellent blood lipid level-lowering and cholesterol-lowering action. <IMAGE>
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