摘要 |
A pharmaceutical compositions with hypotensive effects which comprise a compound of formula (I) or a pharmaceutically acceptable acid addition salt thereof, <IMAGE> (I) wherein R1 is formula (II) <IMAGE> (II) wherein R4 and R5 each represent hydrogen, hydroxy, nitro at the same time R2 and R3 are hydrogen, or R1 are 3-chloro-6-pyridazinylamino, 3-methyl-6-pyridazinylamino or 3-carbamoyl-6-pyridazinylamino, and at the same time R2 and R3 form together formula (III), <IMAGE> (III) wherein R6 is C1-4 alkyl group, R7 is hydrogen or a C1-4 alkyl group, and n is an integer of 1 to 3, or R2 and R3 form together a group of the general formula (IV), =Q-R8 (IV) wherein Q is C5-7 cycloaliphatic, and R8 is hydrogen, a C1-4 alkoxycarbonyl or a C2-4 alkyl, and a compound of formula (V) or a pharmaceutically acceptable acid addition salt thereof, <IMAGE> (V) wherein R9 is naphthyl, 4-indolyl or 4-morpholino-1,2,5-thiadiazol-3-yl group or <IMAGE> (VI) . |