Process for the preparation of novel substituted N-[1-(3,4-methylenedioxyphenyl)-propyl-(2)]-N'-phenylpiperazines

摘要

Novel substituted N-[1-(3,4-methylenedioxyphenyl)-propyl-(2)]-N'-phenylpiperazines of the formula I shown, wherein either R1 and R2 denote chlorine or R1 denotes methyl and R2 denotes methoxy, are prepared by reacting an appropriate bis-(ss-halogenoethyl)amine with an appropriate amine which provides the supplementary moiety. The process is advantageously carried out in the presence of an acid-binding agent and at an elevated temperature. The compounds of the formula I may be obtained in the form of the racemates or of the optically active antipodes. The products of the process show a good central-depressant action as well as an excellent blood lipid level-lowering and cholesterol-lowering action. <IMAGE>