PROCESS FOR THE PRODUCTION OF NOCARDICIN C, D, E, F AND G

摘要

New Nocardicins designated Nocardicin C. Nocardicin D, Nocardicin E, Nocardicin F and Nocardicin G are provided together with a process for their preparation, which comprises cultivating a Nocardicin C, D, E, F and/or G producing strain of the genus Nocardicin in an aqueous nutrient medium under aerobic conditions and recovering the Nocardicin C, D, E, F or G: suitable strains include Nocardia uniforms subsp. tsuyamanensis, for example Nocardia uniforms subsp. tsuyamanensis ATCC 21806 or a mutant thereof; the new Nocardicins posses specific antibiotic spectrums, have low toxicity and are active against pathogenic bacteria.