发明名称 NOVEL PIPERAZINE METHANE ININE DERIVATIVE* ITS MANUFACTURE AND THERAPEUTICAL COMPOSITION CONTAINING IT
摘要 The invention relates to compounds having the formula: <IMAGE> (I) in which: the substituents R1, R2 and R3 represent independently from each other a hydrogen atom, a halogen atom, a trifluoromethyl radical, a saturated or unsaturated straight- or branched-chain C1-6 alkyl radical, a C1-6 alkoxy radical the alkyl moiety of which may be saturated or unsaturated and straight- or branched-chained, a benzyloxy radical or a hydroxy radical; the substituents R5, R6 and R7 represent independently from each other a hydrogen atom, a halogen atom, a trifluoromethyl radical, a straight- or branched-chain saturated or unsaturated C1-6 alkyl radical, a C1-6 alkoxy radical the alkyl moiety of which may be saturated or unsaturated and straight- or branched-chained, or a hydroxy radical; the substituent R4 represents a hydrogen atom, a C1-6 alkyl radical or a hydroxy radical, m and n represent independently a number equal to 0, 1 or 2, X represents an oxygen atom, a sulfur atom or a single bond, and their pharmaceutically acceptable acid addition salts. These compounds are therapeutically useful for the control of the cardiovascular system.
申请公布号 JPS55370(A) 申请公布日期 1980.01.05
申请号 JP19790050937 申请日期 1979.04.26
申请人 LAROCHE NAVARRON SA 发明人 JIYAN KUROODO PASUKARU;ANRI PINASU
分类号 C07D295/12;A61K31/495;A61P9/06;C07C43/225;C07D295/02;C07D295/03;C07D295/092;C07D295/195 主分类号 C07D295/12
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