| 摘要 |
Novel acetylene and vinyl derivatives of amino acids of the following general structure <IMAGE> wherein R is -CH=CH2 or C 3BOND CH; R1 is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, -NR11R12 wherein each of R11 and R12 is hydrogen or a straight or branched lower alkyl group of from 1 to 4 carbon atoms, <IMAGE> wherein R5 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; R2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched or <IMAGE> wherein R6 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; each of R3 and R4 is hydrogen, halogen selected from fluorine, chlorine, bromine and iodine, or a straight or branched lower alkyl of from 1 to 4 carbon atoms and may be the same or different with the proviso that when both R3 and R4 are halogen R3 and R4 are the same; with the proviso that when R is -CH=CH2, R1 is hydroxy and R2 is hydrogen; and pharmaceutically acceptable salts thereof. |
