PROCESS FOR PRODUCING 1-POLYHALOGENOALKYL-3,4-DIHYDRO-2-BRACKET-1H-BRACKET CLOSED-QUINASOLINONES AND -THIONES

摘要

3,4-Dihydro-2(1H)-quinazolinone derivatives of the formula, wherein R1 and R2 are each hydrogen, lower alkyl, lower alkylthio or lower alkoxy, or, when taken together, R1 and R2 may form methylenedioxy; R3 is polyhalo-lower alkyl; R4 is phenyl, halophenyl, lower alkoxyphenyl, lower alkylphenyl or thienyl; and X is oxygen or sulfur, which are known to be very useful intermediates for the preparation of anti-inflammatory and analgesic agents, are obtained in a high yield by reacting a compound of the formula, wherein R1, R2, R3 and X are as defined above, with a compound of the formula, R4-CHO wherein R4 is as defined above, with heating in the presence of a zinc halide as a catalyst.