| 摘要 |
4-Pyridone-3-carboxylic acid derivatives of the formula <IMAGE> in which R<1> denotes C1-6-alkyl or C3-6-cycloalkyl; R<2> denotes hydrogen or C1-6-alkyl; R<3> denotes a phenyl radical which is optionally substituted by R<4>, R<5> and/or R<6>, or an aromatic heterocyclic 6-membered ring containing one or more N atoms, which is optionally substituted by R<7> and which is bonded via a ring C atom; R<4> and R<5> denote halogen, hydroxyl, C1-6-alkoxy, C1-6-alkylthio, C1-6-alkyl, amino, C1-6-alkylamino, di-C1-6-alkylamino, a 5- or 6-membered heterocycle bonded via a ring N or C atom, or both radicals R<4> and R<5> together denote C1-6-alkylenedioxy; R<6> denotes C1-6-alkoxy and R<7> denotes halogen, hydroxyl, C1-6-alkoxy, C1-6-alkylthio, C1-6-alkyl, amino, C1-6-alkylamino or di-C1-6-alkylamino, and their salts, and a process for their preparation by dehydrogenation of corresponding 1,4,5,6-tetrahydronicotinic acid derivatives. The said compounds have antibacterial activity and/or a stimulant effect on the central nervous system. |
