| 发明名称 |
IMPROVED PROCESS FOR PRODUCING VALPROIC ACID |
| 摘要 |
An improved process for producing valproic acid from ethyl acetoacetate is disclosed wherein both the dialkylation of ethylacetoacetate with propyl bromide and the conversion of the dialkylester thus obtained to the corresponding salt take place in a single step, in the presence of a phase-transfer catalyst, in a hydroalcoholic environment, and the salt is converted to valproic acid at pH 1-3.
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| 申请公布号 |
CA2217836(A1) |
申请公布日期 |
1998.04.10 |
| 申请号 |
CA19972217836 |
申请日期 |
1997.10.09 |
| 申请人 |
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A |
发明人 |
BAGOLINI, CARLO ALBERTO;SANTANIELLO, MOSE;FONTANA, SILVERIO;UTTARO, AGOSTINO |
| 分类号 |
A61K31/20;B01J31/22;C07B61/00;C07C51/02;C07C51/09;C07C51/41;C07C53/126;C07C67/343;C07C69/02;(IPC1-7):C07C53/126 |
主分类号 |
A61K31/20 |
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