CONTROLLED RELEASE LIQUID DELIVERY COMPOSITIONS WITH LOW INITIAL DRUG BURST
摘要
The invention provides a controlled release polymeric composition which includes a base polymer or copolymer, an organic solvent, a polymeric controlled release additive, and a biologically active agent. The polymeric controlled release additive reduces the initial burst of biologically active agent released from the polymeric composition as it is solidifying to form the solid implant. The controlled release additive is preferably a poly(lactide-co-glycolide)/polyethylene glycol block copolymer.
申请公布号
WO0024374(A1)
申请公布日期
2000.05.04
申请号
WO1999US25444
申请日期
1999.10.28
申请人
ATRIX LABORATORIES, INC.;CHANDRASHEKAR, BHAGYA, L.;ZHOU, MINGXING;JARR, EILEEN, M.;DUNN, RICHARD, L.
发明人
CHANDRASHEKAR, BHAGYA, L.;ZHOU, MINGXING;JARR, EILEEN, M.;DUNN, RICHARD, L.