| 摘要 |
<p>Novel arabinofuranosyl nucleosides and nucleotides having 2"-azido, 2"-amino, or 2"-hydrocarbylamino substituents, which have antitumor, antiviral, and antimicrobial properties, are prepared by condensation of a pyrimidine, purine, or 1, 3-oxazine base with an acylated 2-azido-2-deoxyarabinofuranosyl halide, followed by deblocking and catalytic hydrogenation, where appropriate, to convert the 2"-azido group to a 2"-amino group and, if desired, alkylation or the like to convert the 2"-amino group to a 2"-hydrocarbylamino group. </p> |
