Prostaglandin I2 analogues

摘要

Prostaglandin I2 analogues of the formula: <IMAGE> II (wherein Y represents trans-vinylene or ethylene, R1 represents hydrogen or an alkyl group containing from 1 to 12 carbon atoms, R2 represents hydrogen, methyl or ethyl, R3 represents a single bond, or an alkylene group containing from 1 to 4 carbon atoms, R4, R5 and R6, which may be the same or different, each represent hydrogen or an alkyl group containing from 1 to 8 carbon atoms, n represents 3, 4, 5 or 6, the wavy line attached to the carbon atoms in positions 11 and 15 depicted in the formula represents alpha - or beta -configuration or mixtures thereof, and the double bond between C6-C6 is Z or E) are new compounds possessing pharmacological properties typical of prostaglandins, for example PGI2.