| 发明名称 |
Methods of using a facilitator of retroviral entry into cells |
| 摘要 |
The present invention demonstrates that a receptor, named DC-SIGN, is specifically expressed on dendritic cells, and facilitates infection of T lymphocytes with HIV. Assays for identifying compounds that modulate the interaction of DC-SIGN and HIV and/or T cells and macrophage are provided. Compounds so identified are also part of the present invention. |
| 申请公布号 |
AU3992101(A) |
申请公布日期 |
2001.09.12 |
| 申请号 |
AU20010039921 |
申请日期 |
2001.02.28 |
| 申请人 |
NEW YORK UNIVERSITY;KATHOLIEKE UNIVERSITEIT NIJMEGEN |
发明人 |
DAN R. LITTMAN;DOUGLAS KWON;YVETTE VAN KOOYK;TEUNIS GEIJTENBEEK |
| 分类号 |
A61K38/17;A61K39/00;A61P31/18;C07K14/705;C07K16/10 |
主分类号 |
A61K38/17 |
| 代理机构 |
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