| 摘要 |
N-(2-Thiazolyl) amides of the formulae: …<CHEM>… are disclosed for use as anti-inflammatory and immunoregulatory agents, in which X is hydrogen or alkyl having from one to six carbon atoms; R is 2-pyrrolidinyl, 2-piperidyl, 2-homopiperidyl, 3-morpholinyl or 3-thiomorpholinyl; R1 is hydrogen, alkyl having from one to four carbon atoms, benzyl or beta -phenyl-ethyl; and R2 is hydrogen, alkyl having one to six carbon atoms, allyl, methallyl, cyclooctyl, cycloalkylmethyl having from five to seven carbon atoms in the cycloalkyl moiety, naphthylmethyl, picolinyl, furfuryl, tetrahydrofurfuryl, thenyl or optionally ring-substituted phenylalkyl having up to three carbon atoms in the alkyl moiety wherein said ring substituent, when divalent, is methylenedioxy or ethylenedioxy, directly attached to adjacent positions of the phenyl ring and when monovalent is fluorine, chlorine, bromine, trifluoromethyl, lower alkyl or lower alkoxy (each having up to three carbon atoms). Such compounds are novel, with the exception of those in which X and R1 are each hydrogen and R2 is alkyl having one to three carbon atoms. |
