gamma -glutamyl-p-aminoanilide derivatives for measuring activity of gamma -glutamyl transpeptidase

摘要

A gamma -glutamyl-p-aminoanilide derivative of the formula: <IMAGE> wherein R1 and R2 are independently lower alkyl; and R3 is hydrogen, lower alkyl, carboxyl or sulfo, can be produced by reacting a N-phthalyl- gamma -glutamyl-p-aminoanilide derivative with hydrazine. The gamma -glutamyl-p-aminoanilide derivative can be used as a substrate for measuring gamma -glutamyl transpeptidase activity in a living sample.