发明名称 |
Composition comprising immunoglobulin |
摘要 |
Liquid compositions for intravenous administration that comprise an aqueous solution of immunoglobulin and methods of preparing such compositions are disclosed. The solution has a pH in the range of 5.0 to 5.8 and an ionic strength is the range 0.02 to 0.25. The liquid compositions are formulated so as to be stable upon storage such that the immunoglobulin does not substantially aggregate nor degrade and maintains acceptable levels of anti-complementary activity, PKA activity and kallikrein activity during storage for an extended period at a temperature in the range of 4° C. to 25° C.
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申请公布号 |
US6485932(B1) |
申请公布日期 |
2002.11.26 |
申请号 |
US19990381600 |
申请日期 |
1999.10.25 |
申请人 |
COMMON SERVICES AGENCY |
发明人 |
MCINTOSH RONALD VANCE;WELCH ANNE GILLIAN |
分类号 |
A61K9/08;A61K39/395;A61K47/04;A61K47/42;A61P43/00;C07K16/06;(IPC1-7):C12P21/06;A61K38/46;A61K39/40;A61K39/42 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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