| 摘要 |
The compounds correspond to the formula: <IMAGE> in which R represents hydrogen or a C1-C3 alkyl, n represents the number 2 or 3 and X represents hydrogen, fluorine, chlorine or bromine or a methoxy, trifluoromethyl, nitro or amino radical. They are prepared by reaction of a 4-[3-R-1,3-dihydro-2-oxo-1-(2H)-benzamid-azolyl]-1-piperidine-ethanami ne or -propanamine with a halide of a para-X-benzoic acid. The ethanamine or propanamine involved can be obtained by reaction of a 4-[3-R-1,3-dihydro-2-oxo-1-(2H)-benzamid-azolyl]piperidine with an N-haloethylphthalimide, then treatment of the intermediate product formed with hydrobromic acid in acetic medium and basification. The compounds I and their salts with acids have an antiemetic action and are free of psychotropic properties; they can be used in the treatment and the prevention of cases of vomiting and nausea.
|
