| 摘要 |
PURPOSE:To prepare a urokinase injection having excellent stability, by freeze-drying of a composition composed of a urokinase solution, human serum albumin and a polar amino acid. CONSTITUTION:An aqueous solution of urokinase is mixed with human serum albumin (HSA) and a polar amino acid (salt) as stabilizers, and freeze-dried to obtain the stabilized urokinase injection. The polar amino acid is pref. threonine, arginine, histidine, and/or glutamic acid, esp. glutamic acid. The amounts of HSA and the amino acid are, e.g. several ten mg and at least several mg, respectively; and when the amount of the HSA is higher, that of the amino acid is lower, and vice versa.
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