| 摘要 |
Title compds. (I;R1 =H or C1-6 alkyl or C3-8 cycloalkyl group R2 = C1-6 alkyl or C3-8 cycloalkyl group, R1 ,R2 can form hetero cyclic rings with N, R3 = C1-8 alkyl, C3-8 alkenyl-alkyl or C5-8 cycloalkyl group ,Z =halogen ,alkoxy, aryloxy, or trichloromethyl group), useful as antidiabetics, were prepd. treating the sulfonamide[II with azide as R3NCO (or R3CON3) or carbamic acid deriv. of R3NHCOZ. Thus I (R1 = R2 =me, R3 = cyclohexyl) at 1μmole/kg orally in dogs decreased the plasma glucose level to 69% of controls in2hr
|
