The present invention relates to a genetically modified pig as a model for studying atherosclerosis. The modified pig model displays one or more phenotypes associated with atherosclerosis. Disclosed is also a modified pig comprising a mutation in the endogenous ApoE gene or part thereof and/or LDL gene or part thereof, and/or LDL receptor gene, and/or transcriptional and/or translational product or part thereof. The invention further relates to methods for producing the modified pig; and methods for evaluating the effect of a therapeutical treatment of atherosclerosis; methods for screening the efficacy of a pharmaceutical composition; and a method for treatment of a human being suffering from atherosclerosis are disclosed.
申请公布号
CA2716990(A1)
申请公布日期
2008.09.12
申请号
CA20082716990
申请日期
2008.03.06
申请人
AARHUS UNIVERSITET
发明人
FOG, JACOB BENTZON;SOERENSEN, CHARLOTTE BRANDT;KRAGH, PETER MICHAEL;MIKKELSEN, JACOB GIEHM;FALK, ERLING;BOLUND, LARS AXEL;CORYDON, THOMAS JUHL