发明名称 |
PHARMACOLOGICAL MODULATION OF POSITIVE AMPA RECEPTOR MODULATOR EFFECTS ON NEUROTROPHIN EXPRESSION |
摘要 |
<p>Antagonists of group 1 metabotropic glutamate receptors (mGluR) potentiate the effect of positive AMPA receptor modulators on neurotrophin expression, such as brain-derived neurotrophic factor (BDNF). The findings described herein suggest a combinatorial approach for drug therapies, using both positive AMPA receptor modulators and mGluR antagonists, to enhance brain neurotrophism.</p> |
申请公布号 |
EP2010174(A2) |
申请公布日期 |
2009.01.07 |
申请号 |
EP20070760896 |
申请日期 |
2007.04.19 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
LAUTERBORN, JULIE C.;GALL, CHRISTINE M.;LYNCH, GARY |
分类号 |
A61K51/00;A61K31/4439;A61K35/30;A61K38/00;A61K45/06;A61P25/28 |
主分类号 |
A61K51/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|