| 摘要 |
Certain trans-2,3,4,4a,5,9b-hexahydro-1H-pyrido-[4,3-b]indoles are useful as analgesics and sedatives. Some are also useful as major (antipsychotics) and/or minor (anxiolytics) tranquilizers, muscle relaxants, or hypotensives. The compounds of this invention are made by (1) reaction of DELTA 4a,9b-tetrahydro precursors with borane/THF and (2) acidifying the reaction product by which it is reduced and hydrolyzed to form the corresponding trans-hexahydro compound.
|
