TREATMENT AND PREVENTION OF CHRONIC ASTHMA USING ANTAGONISTS OF INTEGRIN aVß6
摘要
<p>The present invention relates to methods of asthma treatment and prevention using avß6 antagonists, such as avß6-binding antibodies. In particular, the invention relates to the discovery of a correlation between reduced expression of avß6and the protection from the increase in airway sensitivity seen in chronic allergen-challenged mice. This protection is associated with protection from the usual allergen-induced increase in airway epithelial mast cells.</p>
申请公布号
WO2008147434(A9)
申请公布日期
2009.03.05
申请号
WO2007US81473
申请日期
2007.10.16
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;BIOGEN IDEC MA INC.;SHEPPARD, DEAN;HUANG, XIAOZHU;VIOLETTE, SHEILA, M.
发明人
SHEPPARD, DEAN;HUANG, XIAOZHU;VIOLETTE, SHEILA, M.