| 摘要 |
<p>Prepn. of (I)-homoeburnamine (I) involves reaction of a 1-ethyl-2,3,4,6,7-hexahydroindolo 2,3-a quinolizinium salt (II) with acrolein to form a 3,4-dehydrohomoeburnamine salt (III). Then (III) is reduced to (I). Redn. of (III) with Zn powder in EtOH selectively gives (+)-(I), while redn. with NaBH4 gives 16-epihomoeburnamine. (I) is obtd. conveniently, economically and in good yield. (I) is an intermediate in the prepn. of plus-or-minus-vincamine by treatment with Ag2CO3.</p> |
