| 摘要 |
<p>Novel 1-(2Ar-4-R-1,3-dioxolan-2-ylmethyl) imidazoles are disclosed of the formula: (I) and the therapeutically acceptable acid addition salts thereof, wherein: Ar is a member selected from the group consisting of phenyl, substituted phenyl, thienyl, halothienyl and naphthyl, and wherein said substituted phenyl is phenyl having from 1 to 3 substituents independently selected from the group consisting of halo. loweralkyl, loweralkyloxy, nitro and vano; and R is a member selected from the group consisting of alkyl having from 2 to about 10 carbon atoms, alkyloxymethyl wherein the alkylgroup has from 1 to about 10 carbon atoms, alkenyl, alkenyloxymethyl, wherein said alkenyl has from 2 to about 10 carbon atoms, hydroxymethyl, 2-propynyloxymethyl, halomethyl, aryl, arylloweralkyl, aryloxymethyl, arylthiomethyl and arylmethoxymethyl, wherein said aryl is a member selected from the group consisting of of phenyl, substituted phenyl, naphthyl. and mono- and di-halonaphthyl and wherein said substituted phenyl is phenyl having from 1 to 3 substituents independently selected from the group consisting of halo, loweralkyl, loweralkyloxy, cyano, nitro, phenyl, phenylmethyl, benzoyl, halobenzoyl, loweralkylcarbonyl, loweralkyloxycarbonyl and trifluoromethyl, provided that when more than one substituents are present only one thereof may be selected from the group consisting of phenyl, phenylmethyl, benzoyl and halobenzoyl.</p> |
