发明名称 |
Phosphonium salt and its use |
摘要 |
The amidation and esterification of carboxylic acids with amines and hydroxyl group-containing compounds, respectively, are effected without incurring the drawbacks of reaction equilibrium by the reaction of the reactants, one of which has been activated in the reactive group by contact with a phosphonium salt obtained by reacting a phosphorous ester or phosphorous monoester salt with an organic base such as pyridine and an oxidizing agent such as halogens and mono or divalent mercury halide or acetate. The amidation can be applied to the preparation of peptides by the reaction of amino acids and/or peptides in which one of the reactive groups have been protected.
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申请公布号 |
US4173563(A) |
申请公布日期 |
1979.11.06 |
申请号 |
US19780914773 |
申请日期 |
1978.06.12 |
申请人 |
SUMITOMO CHEMICAL CO LTD |
发明人 |
HIGASHI, FUKUJI;YAMAZAKI, NOBORU |
分类号 |
C07D209/20;C07C67/00;C07C231/00;C07K1/06;C07K1/08;C07K1/10;C07K5/06;(IPC1-7):C07C103/52;C07G7/00 |
主分类号 |
C07D209/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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