NEW PROCESS FOR OBTAINING TIMINE DERIVATIVES

摘要

This invention relates to a new synthetic process for the manufacture of zidovudine from the starting material D-xylose involving: i) Conversion of D-xylose to a 2',3',5'-protected derivative of 1-( beta -D-xylofuranosyl)thymine; ii) 2'-Deoxygenation of the xylofuranosyl thymine; and iii) 3'-Azidation of the 2'-deoxy compound. o