| 摘要 |
Stabilized prostacyclins having a wide range of pharmacological activity and long duration of such activity, have the formula <IMAGE> wherein R1 is (a) OR3, wherein R3 is hydrogen, alkyl, cycloalkyl, aryl or a heterocyclic residue; or (b) NHR4 wherein R4 is an acid residue; B is straight-chain or branched alkylene of 2-10 carbon atoms; A is -CH2-CH2-, cis-CH=CH-, trans-CH=CH- or -C 3BOND C-, W is free or functionally modified hydroxymethylene or free or functionally modified <IMAGE> wherein the OH-group can be in the alpha - or beta -position; D and E together are a direct bond; or D is straight-chain or branched alkylene of 1-5 carbon atoms; and E is oxygen or sulfur or a direct bond, R2 is alkyl, cycloalkyl, optionally substituted aryl or a heterocyclic group; and R5 is free or functionally modified hydroxy; and when R3 is hydrogen, the salts thereof with physiologically compatible bases. |
