Process for the preparation of [1-oxo-2-aryl- or -thienyl-2-subst.-5-indanyloxy- (or -thio)]alkanecarboxylic acids or their alkyl esters

摘要

[1-Oxo-2-aryl- or -thienyl-2-subst.-5-indanyloxy- (or -thio)]alkanecarboxylic acids or their alkyl esters of the formula <IMAGE> are prepared. The substituents in the formula are described in Claim 1. These compounds are obtained by reacting an appropriately substituted [1-oxo-2-aryl- or -2-thienyl-5-indanyloxy- (or -thio)]alkanecarboxylic acid or a lower alkyl ester thereof with an alkylating agent which supplies the radical R. The resulting compounds, which are in the form of the free acid, can be converted into lower alkyl esters or salts. The corresponding amides are likewise prepared from compounds of the formula I which are in the form of the free acid by converting the acid with thionyl chloride into the acid chloride and then reacting the latter with an amine. The resulting compounds have therapeutic activity and can be used, in particular, in diuretic and saluretic agents.