| 摘要 |
<p>TITLE: Purification of d,d'-2,2'(ethylenediimino)di- -1-Butanol Dihydrochloride INVENTOR: John Kazan A superior grade of d,d'-2,2'-(ethylenediimino)di--1-butanol dihydrochloride from the reaction of ethylene dicloride and an excess of d-2-amino-1-butanol is obtained by mixing finely divided sodium hydroxide with the reaction mixture, vacuum distilling off d-2-amino-1-butanol, adding a 2-4 carbon alkanol, preferably isopropanol, separating sodium chloride, adding water or an aqueous 2-4 carbon alkanol thereto to a water content of about 7-10% by weight, and an essentially stoichiometric amount of hydrogen chloride, to precipitate d,d'-2,2'-(ethylenediimino)di-1-butanol dihydrochloride, cooling the reaction mixture, and separating a pharmaceutical grade product.</p> |
