NOGO-A BINDING MOLECULES AND PHARMACEUTICAL USE THEREOF

摘要

THE PRESENT INVENTION PROVIDES A BINDING MOLECULE WHICH IS CAPABLE OF BINDING TO THE HUMAN NogoA POLYPEPTIDE OR HUMAN NiG OR HUMAN NiG-D20 OR HUMAN NogoA_342-357 WITH A DISSOCIATION CONSTANT < 1000nM, A POLYNUCLEOTIDE ENCODING SUCH BINDING MOLECULE; AN EXPRESSION VECTOR COMPRISING SAID POLYNUCLEOTIDE; AN EXPRESSION SYSTEM COMPRISING A POLYNUCLEOTIDE CAPABLE OF PRODUCING A BINDING MOLECULE; AN ISOLATED HOST CELL WHICH COMPRISES AN EXPRESSION SYSTEM AS DEFINED ABOVE; THE USE OF SUCH BINDING MOLECULE AS A PHARMACEUTICAL, ESPECIALLY IN THE TREATMENT OF NERVE REPAIR; A PHARMACEUTICAL COMPOSITION COMPRISING SAID BINDING MOLECULE; AND A METHOD OF TREATMENT OF DISEASES ASSOCIATED WITH NERVE REPAIR.