发明名称 THE PREPARATION OF N-ALKENYL-2-AMINOMETHYL PYRROLIDINES
摘要 An N-alkenyl-2-aminomethyl-pyrrolidine is prepared by firstly reacting tetrahydrofurfurylamine with gaseous hydrochloric acid and thionyl chloride to produce 2,5 dichloropentylamine hydrochloride. This is acetylized, possibly by acetyl chloride in dichloroethane in the presence of triethylamine, into N-acetyl-2,5-dichloropentylamine which is condensed with an alkenylamine into an N-alkenyl-2-acetylaminomethyl pyrrolidine from which the acetyl group is separated, for example by boiling with concentrated hydrochloric acid.
申请公布号 PH12945(A) 申请公布日期 1979.10.18
申请号 PH19870000183 申请日期 1976.04.20
申请人 SACHIM SA 发明人 DENZLER E
分类号 C07D207/08;A61K31/40;C07D207/09 主分类号 C07D207/08
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