| 摘要 |
<p>NEW MATERIAL:The compound of formula I [R<1> is (protected carboxy; R<2> is (protected) hydroxy-lower alkyl; R<3> is H or lower alkyl; R<4> is (substituted) aliphatic heterocyclic group; R<5> is H, lower alkyl or imino-protecting group; A is lower alkylene]. EXAMPLE:(4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3-[(2S,4S)-1-(4- nitrobenzyloxycarbonyl)-2{4-(4-nitrobenzyloxycarbonyl)-piperazin-1-yl} methylpyrrolidin-4-yl]thio-7-oxo-1-azabicyclo-[3,2,0]hept-2-ene-2-carb oxylic acid nitrobenzyl ester. USE:An antibacterial agent. PREPARATION:A compound of formula II or its reactive derivative at the oxo group is made to react with a compound of formula III or its salt.</p> |
