| 摘要 |
<p>Compounds of the formula (1):
<Chemistry id="chema01" num="0001"><Image id="ia01" he="30" wi="82" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein:
<UnorderedLists id="ula01" listStyle="none"><ListItem>Y is -CH<Sub>2</Sub>CH<Sub>2</Sub>-, -CH=CH- or -C=C.</ListItem><ListItem>n is 1 to 5;</ListItem><ListItem>R, is hydrogen, or CO<Sub>2</Sub> R, represents an ester group in which the R, moiety contains from 1 to 12 carbon atoms;</ListItem><ListItem>R<Sub>2</Sub> is hydrogen, C<Sub>1-4</Sub> alkyl, trifluoromethyl, or phenyl;</ListItem><ListItem>R<Sub>3</Sub> is hydroxy or protected hydroxy;</ListItem><ListItem>R<Sub>5</Sub> is hydrogen, C<Sub>1-6</Sub> alkyl, phenyl or phenyl C<Sub>1-6</Sub> alkyl, any of which phenyl moieties may be substituted by one or more halogen, trifluoromethyl, C<Sub>1-5</Sub> alkyl, C<Sub>1-6</Sub> alkoxy or nitro groups; and</ListItem><ListItem>X is CH<Sub>2</Sub> and</ListItem><ListItem>R<Sub>4</Sub> is C,.<Sub>s</Sub> alkyl, C<Sub>3-8</Sub> cycloalkyl-C<Sub>1-6</Sub> alkyl, phenyl-C<Sub>1-6</Sub> alkyl or naphthyl-C<Sub>1-6</Sub> alkyl, any of which groups may have one acyclic carbon-carbon bond interrupted by an oxygen atom; hydrogen, C<Sub>3-8</Sub> cycloalkyl, phenyl or naphthyl, any of which phenyl of naphthyl moieties in R<Sub>4</Sub> may be substituted by one or more halogen, trifluoromethyl, C<Sub>1-6</Sub> alkyl, hydroxy, C<Sub>1-6</Sub> alkoxy or nitro groups; or R<Sub>2</Sub> and R<Sub>4</Sub> taken with the carbon atom to which they are joined represent a C<Sub>5-8</Sub> cycloalkyl group; or</ListItem><ListItem>X is CS and</ListItem><ListItem>R<Sub>4</Sub> is C<Sub>1-9</Sub> alkyl, C<Sub>3-8</Sub> cycloalkyl-C<Sub>1-6</Sub> alkyl, phenyl-C<Sub>1-6</Sub> alkyl or naphthyl-C<Sub>1-6</Sub> alkyl, having one acyclic carbon-carbon bond interrupted by an oxygen atom, and in which any phenyl or naphthyl moieties may be substituted by one or more halogen, trifluoromethyl, C<Sub>1-6</Sub> alkyl, hydroxy, C<Sub>1-6</Sub> alkoxy or nitro groups; and salts thereof; having similar pharmacological activity to natural prostaglandins, processes for their preparation, intermediates useful in those processes and pharmaceutical compositions containing compounds of the formula (I).</ListItem></UnorderedLists></p> |
