| 摘要 |
<p>NEW MATERIAL:5-Fluorouracil derivative of formula I (R<1>,<2> are H, lower alkoxy; provided that both R<1> and R<2> are not H at the same time; R<1> and R<2> may together from lower alkylene dioxy group). EXAMPLE:5-Fluoro-2-piperonyloxy-3H-pyrimidin-4-one. USE:Low-toxic carcinostatic agent having stronger carcinostatic activity than 5- fluorouracil or its 2-benzyl derivative. PROCESS:The compound I is prepared by heating a compound II (X is halogen) with a compound III (M is alkali metal) in a solvent such as toluene, THF, etc., at 60-140 deg.C, pref. refluxing near the boiling point of the solvent.</p> |
