| 摘要 |
NEW MATERIAL:3-Oxo-2,3-dihydro[1]benzothiophene-2-spirocyclopropane of formula I. USE:Prophylactic and remedy for disturbance of circulation, e.g. thrombosis, cerebral hemorrhage, stenocardia, etc. Also useful as an intermediate of pharmaceuticals. PROCESS:The compound I is prepared by the de-hydrohalogenation of the compound II (X is halogen) with a dehalogenating agent (e.g. organic sulfonic acid metal salt, alkali metal carbonate, etc.) in a solvent such as DMF, at 100-200 deg.C pref. 140-160 deg.C. Substitution of the atomosphere in the reacton vessel with inert gas is sometimes effective for the prevention of side reactions and the improvement of the yield.
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