发明名称 |
Microbiological conversion of sterol derivatives to 5-androsten-17-one derivatives and their use |
摘要 |
Sterol derivatives of the formula <IMAGE> wherein R1 is a hydrogen atom and R2 is lower alkoxy, or R1 and R2 collectively are lower alkylenedioxy and R3 is a sterol hydrocarbon side chain are converted to the corresponding androsten-17-ones by the oxidative degradation activity of a species of microorganism which degrades sterol side chains, preferably of the genus Mycobacterium. The ether group of those compounds wherein R1 is a hydrogen atom and R2 is lower alkoxy, and the corresponding 17 beta -hydroxy and 17 alpha -hydrocarbon-17 beta -hydroxy compounds is cleaved by reaction with an alkanoic acid chloride or anhydride in the presence of a Lewis acid.
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申请公布号 |
US4170518(A) |
申请公布日期 |
1979.10.09 |
申请号 |
US19760710559 |
申请日期 |
1976.07.30 |
申请人 |
SCHERING AG |
发明人 |
EDER, ULRICH;HAFFER, GREGOR;KENNECKE, MARIO;MULLER, RUDOLF;NEEF, GUNTER;POPPER, ALFRED;SAUER, GERHARD;WEBER, ALFRED;WIECHERT, RUDOLF |
分类号 |
C12P33/16;A61K31/5685;C07J1/00;C07J7/00;C07J9/00;C07J13/00;C07J21/00;C12P33/00;C12R1/01;C12R1/06;C12R1/07;C12R1/32;(IPC1-7):C07B29/02 |
主分类号 |
C12P33/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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