发明名称 |
Heterocyclic-methylthioalkyl-guanidines |
摘要 |
The compounds are N-(heterocyclomethylthioalkyl)derivatives of alkylguanidines, C-alkyl and C-aryl amidines and S-alkylisothioureas. The compounds may also have N'-lower alkyl or N'-(heterocyclomethylthioalkyl)substituents. Three compounds of the invention are S-methyl-N-[2-(5-methyl-4-imidazolylmethylthio)ethyl]isothiourea, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]acetamidine, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]N''-methylguanidine. The compounds of this invention are histamine H2-antagonists.
|
申请公布号 |
US4170652(A) |
申请公布日期 |
1979.10.09 |
申请号 |
US19780896848 |
申请日期 |
1978.04.17 |
申请人 |
SMITH KLINE & FRENCH LABORATORIES LTD |
发明人 |
DURANT, GRAHAM J;GANELLIN, CHARON R;YOUNG, RODNEY C |
分类号 |
A61K31/33;C07D249/08;C07D261/14;C07D275/02;C07D277/26;C07D277/48;C07D285/12;(IPC1-7):C07D213/53;A61K31/41;A61K31/44 |
主分类号 |
A61K31/33 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|