| 摘要 |
Title compds. (R1,R2,R3,R4,R5 = H, halogen, CF3,NO2, lower alkyl, lower alkoxy (where three of R2,R3,R4,R5 must be H); n = 2,4), useful as anti-arrhythmic agent and sedative, were prepd. by cyclization of II (X = Cl, I, Br) in inactive solvent such as ether and HCON(CH3)2, inorganic acid-binding agent, and Na2So4 under unhydrous condition at 50-100≦̸C. Thus, α-(2-BrCH2C6H4)CHPhBr was treated with propylene thiourea and Na2CO3 to give II, which was cyclized by base to I (R1-R5 = H; n = 3).
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