A NOVEL PROCESS FOR PRODUCING 7-(D(-)-A-(4-ETHYL-2,3-DIOXO-1-PIPERAZINECARBOXAMIDO)A-(4-HYDROXOPHENYL)ACETAMIDO/-3-/5-(1-METHYL-1,2,3,4-TETRAZOLYL)THIOMETHYL/-DELTA3-CEPHEM-4-CARBOXYLIC ACID AND A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND AN INTERMEDIATE THEREOF AND A PROCESS FOR PRODUCING THE INTERMEDIATE

摘要

NEW MATERIAL:N,N-dimethylacetamide adduct of 7-[D(-)-alpha-(4-ethyl-2,3-dioxo- 1-piperazine-carboxamido)-alpha-(4-hydroxyphenyl)acetamido]-3-[5-(1-me tyl-1,2,3,4- tetrazolyl)-thiomethyl]- DELTA<3>-cephem-4-carboxylic acid of formula I. USE:An intermediate of antibacterial substance. A low toxic antibcterial agent effective to Gram positive and Gram negative bacteria a is obtained by eliminating N,N- dimethylacetamide group from the compound I. PROCESS:The compound I is prepared by reacting a compound II with a reactive derivative of te compound III using N,N-dimethylacetamide as solvent.