摘要 |
Title compds. (I; py = 4-,3-,2-pyridinyl, etc., R = H, lower alkyl, lower hydroxyalkyl, Q = nitro cyano, H, carbamyl, etc.) and their pharmaceutically acceptable salts, useful as cardiacs, were prepd. In a typical example, α-py-β-(R1R2N) acrolein(II; R1,R2 = Me, Et) or α-py-malonaldehvde (II') was reacted with α-cyanoacetamide to form 1,2-dihydro-2-oxo-5-py-nicotinontrile (III; Q = CN, R = H), followed by hydrolysis of III to give 1,2-dihydro-2-oxo-5-py-nicotinamide (I; Q = CONH2).
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