| 摘要 |
PURPOSE:To enable high yield production of L-glutamic acid even in a medium containing excess biotin, by culturing a specific variant induced from L-glutamic acid-producing bacteria belonging to Corynebacterium or Brevibacterium genus. CONSTITUTION:A lysozyme-sensitive strain such as corynebacterium glutamicum KY9703, KY9705, T339 or T327 (FERM-P No.4412, 4413, 4789, or 4790) induced from Corynebacterium glutamicum ATCC13032, or Brevibacterium flavum KY9733 (FERM-P No.4414) induced from Brevibacterium flavum ATCC14067, is inoculated in a nutrient medium, and aerobically cultured at pH6-9 and 24-37 deg.C. Even if the medium contains excessive biotin, the production of L-glutamic acid is not inhibited, and the L-glutamic acid can be obtained in high yield. |
