发明名称 |
5-Formyl-prostacyclin derivs. - useful as long lasting hypotensives, bronchodilators, diuretics etc. |
摘要 |
<p>Prostane derivs. of formula (I) and their salts with pharmaceutically acceptable bases when R1 = H, are new. In (I), R1 is H or alkyl; B is opt. branched, satd. or unsatd. 2-6C alkylene; A is CH2CH2, trans-vinylene or C triple bond C; W is CH2OH or both opt. functionally modified; D is opt. branched 1-5C alkylene or bond; R2 is alkyl, cycloalkyl or opt. substd. aryl; and R3 is opt. functionally-modified OH. (I) are made by reacting the corresp. 5-H cpd. with a Vilsmeyer-Haack reagent. (I) have the same hypotensive, bronchodilating, antisclerotic, diuretic, antiarrythmic, antisecretory and thrombocyte-aggregation inhibiting activities as PGI2 but are more stable with a longer-lasting effect. They have superior tissue specificity e.g. reduced stimulation of guinea pigileum or isolated rabbit trachea. They can be administered orally or parenterally.</p> |
申请公布号 |
DE2809733(A1) |
申请公布日期 |
1979.09.13 |
申请号 |
DE19782809733 |
申请日期 |
1978.03.03 |
申请人 |
SCHERING AG |
发明人 |
VORBRUEGGEN,HELMUT,PROF.;SKUBALLA,WERNER,DR.;RADUECHEL,BERND,DR.;LOSERT,WOLFGANG,PROF.;LOGE,OLAF,DR.;MUELLER,BERND,DR.;MANNESMANN,GERDA,DR. |
分类号 |
C07D307/937;(IPC1-7):C07D307/93;A61K31/015 |
主分类号 |
C07D307/937 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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