| 摘要 |
Alkylphenones [I; R1 = H, F or Cl, R2,R3 = C1-2 alkyl, R4 = C1-4 alkyl , useful as blood lipid lowering agents at 300-2000mg, were prepd. by reaction of halo derivs. (II; X = Cl or Br) with R4NH2. Thus, a mixt. of 300ml MeNH2 and C6H6 was added to II, prepd. by acylation of ρ-Me C6H4Br with Me3CCOCl followed by bromination with NBS, and the mixt. heated to boiling for 24hr to give I as HCl salt.
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