| 摘要 |
<p>The invention relates to compounds of formula (I) (I) wherein X is sulphur or oxygen; R1 is halogen, hydroxy, hydrogen, thio, alkylthio, amino, alkyiamino or dialkylamino or azide; R2 is hydrogen, halogen, amino or azide; R3 is hydrogen, straight or branched chain or cyclic alkyl, hydroxyalkyl, benzoylalkyl or phenyl; R4 is hydrogen, hydroxy, or lower alkyl; R5 is hydrogen, hydroxy, amino, alkyl, hydroxyalkyl, benzoyloxy, benzoyloxyalkyl, benzyloxy, sulphamoyloxy, phosphate, carboxypropionyloxy, acetoxy, or substituted carbamoyl group of formula NH.CO-Z wherein Z is alkyl, ary or aralkyl optionally substituted by one or more of sulphonyl, amino, carbamoy1, or hydrogen; R6 is hydrogen, alkyl, hydroxyalkyl, which have antiviral activity in mammals. All compounds of formula (I) are novel with the exception of that wherein X is oxygen and R2, R3, R4 and R6 are hydrogen, R1 is not amino or methylamino, when R5 is hydroxy. Provided are pharmaceutical compositions comprising a compound of formula (I) together with an acceptable carrier therefor, and the use of the compounds in medicine. Also provided are methods for the synthesis of the novel compounds. Compounds of formula (I) have good antiviral activity against several types of viruses, in particular those in the Herpes group.</p> |
