| 摘要 |
NEW MATERIAL:Thioxanthene derivatives I [X is H, lower alkyl, halogen, trifluoromethyl, SR<1> (R<1> is lower alkyl), etc.; Y is H, F; Z is II, etc.; L is OH, III, etc.; n is 2, 3; the dotted line in the ring may be a double bond], and their salts. EXAMPLE:4[4-(2-hydroxyethyl)-1-piperazinyl]-2'-trifluoromethyl-spiro[c yclohexane- 1,9'-thioxanthene]. USE:Long-acting anti-psychotic agent, sedative, etc., having strong CNS-depressing activity such as spontaneous movement depressing activity, anti-morphine effect, etc. PROCESS:The compound I can be prepared, e.g. by reacting a compound IV (T is a reactive ester, pref. Cl) with a compound V. |
