摘要 |
Nitroso urea derivs. (I,[A = ribostamycin residue; R = C1-4 lower alkyl or C1-4 halogeno- ! lkyl), showing strong anti-tumor and anti-leukemia activity, were prepd. by nitrosoftying the tetra-N-lower alkyl or halogenoalkyl substituted ureid derivs (II) of ribostamycin. The starting material II was obtained by reacting the ribostamycin with lower alkyl isocyanate or halogeno alkyl isocyanate in org. solvent such as MeOH.
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