PROCESS FOR PREPARING UNSYMMETRICAL ESTERS OF 1,4-DIHYDROPYRIDINE DICARBOXYLIC ACID

摘要

Fifty-three title compds. (I; R = e.g., m-O2-NC6H4, 2,5-Cl(O2N)C6H3, O-NCC6H, or 2-pyridyl; R1, R3 = Me; R2 = e.g., Me or Me2CH; R4 = e.g., Et, CH2; CHCH2, Me OCH2CH2, or cyclohexyl), useful as cornary dilators, antihypotensives, spasmolytics, and drugs against cardiac fibrillation, were prepd. in 24-78% yield by reaction of RCH:C(COMe) CO2R2 with MeCOCH2COOR4 and NH3 in H2O or alcs as thickener.